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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
E2F1
All Species:
33.94
Human Site:
S131
Identified Species:
62.22
UniProt:
Q01094
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01094
NP_005216.1
437
46920
S131
E
K
S
R
Y
E
T
S
L
N
L
T
T
K
R
Chimpanzee
Pan troglodytes
XP_524538
437
47536
S133
E
K
T
R
Y
D
T
S
L
G
L
L
T
K
K
Rhesus Macaque
Macaca mulatta
XP_001103717
502
53768
S196
E
K
S
R
Y
E
T
S
L
N
L
T
T
K
R
Dog
Lupus familis
XP_542963
571
61192
S266
E
K
S
R
Y
E
T
S
L
N
L
T
T
K
R
Cat
Felis silvestris
Mouse
Mus musculus
Q61501
430
46305
S126
E
K
S
R
Y
E
T
S
L
N
L
T
T
K
R
Rat
Rattus norvegicus
Q62814
300
33206
L12
R
H
E
K
S
L
G
L
L
T
T
K
F
V
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515449
468
50133
A130
G
K
Q
P
R
P
G
A
P
Q
N
T
A
K
R
Chicken
Gallus gallus
Q90977
403
43534
S108
E
K
S
R
Y
E
T
S
L
N
L
T
T
K
R
Frog
Xenopus laevis
NP_001090608
426
47125
S123
E
R
S
R
Y
D
T
S
L
H
L
T
T
K
R
Zebra Danio
Brachydanio rerio
NP_001074097
429
46452
S134
E
K
T
R
Y
D
T
S
L
G
F
L
T
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27368
805
87442
S258
D
R
N
R
A
D
T
S
L
G
I
L
T
K
K
Honey Bee
Apis mellifera
XP_396223
416
46049
K128
G
H
T
P
T
K
S
K
T
V
E
R
T
R
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001123287
404
44387
P108
S
S
T
A
F
K
T
P
S
P
R
P
S
A
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.7
86
70.9
N.A.
84.6
23.1
N.A.
39.9
59.9
49.8
37.2
N.A.
20.6
29.7
N.A.
38.4
Protein Similarity:
100
54.4
86.2
72.6
N.A.
88.5
37.9
N.A.
51.2
70
63.3
53.7
N.A.
31.5
46.4
N.A.
54.2
P-Site Identity:
100
66.6
100
100
N.A.
100
6.6
N.A.
26.6
100
80
60
N.A.
40
6.6
N.A.
6.6
P-Site Similarity:
100
86.6
100
100
N.A.
100
13.3
N.A.
33.3
100
100
80
N.A.
80
33.3
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
0
0
8
0
0
0
0
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
31
0
0
0
0
0
0
0
0
0
% D
% Glu:
62
0
8
0
0
39
0
0
0
0
8
0
0
0
0
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
8
0
8
0
0
% F
% Gly:
16
0
0
0
0
0
16
0
0
24
0
0
0
0
0
% G
% His:
0
16
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% I
% Lys:
0
62
0
8
0
16
0
8
0
0
0
8
0
77
31
% K
% Leu:
0
0
0
0
0
8
0
8
77
0
54
24
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
0
0
39
8
0
0
0
0
% N
% Pro:
0
0
0
16
0
8
0
8
8
8
0
8
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% Q
% Arg:
8
16
0
70
8
0
0
0
0
0
8
8
0
8
54
% R
% Ser:
8
8
47
0
8
0
8
70
8
0
0
0
8
0
8
% S
% Thr:
0
0
31
0
8
0
77
0
8
8
8
54
77
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
62
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _